Cristiano Ronaldo's 125th Champions League goal wasn't enough for Juventus as they had to settle for a 1-1 draw against Ajax in the first-leg of their quarter-final. United already came back from a heavier first-leg deficit to reach this stage, losing 2-0 to Paris Saint-Germain in the round of 16 before winning 3-1 in the French capital last month.
Ronaldo collected a pass from the elegant Rodrigo Bentancur, spread the play to Joao Cancelo and then ran unhindered in a straight line into the box to head home his compatriot's perfectly flighted cross.
Ronaldo's path to a fourth European trophy in as many seasons remains on a knife edge against a fearless Ajax who dumped Real out in the previous round after a thrilling 4-1 victory in Spain.
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However, David Neres curled home for the hosts at the beginning of the second period to leave the quarterfinal tie delicately poised at 1-1.
Cristiano Ronaldo's Juventus head to SPAL on Saturday needing just a point to wrap up an eighth consecutive Serie A title in record time before their crucial Champions League decider against Ajax in Turin next week.
He is now 17 goals ahead of his nearest rival Lionel Messi. "His timing and movement is different to everyone else's - there's nothing you can do about it", Juve boss Massimiliano Allegri told Sky Sport Italia.
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Portugal star Ronaldo had returned to action following three weeks out after picking up an injury during the worldwide break. "I thought it would be four as something similar happened with [Gerard] Pique and he missed four games".
He will hope to be back to his best on Tuesday night when Barca hope to defend their lead at the Nou Camp. An early own goal from Luke Shaw gave Barcelona the advantage heading into the second leg, with little in the way of goalmouth action throughout the evening in England. "I think United had one player that was responsible for that because I think Scott McTominay in midfield he was like what I used to call - but when I use this expression it's obviously in the total positive sense of the word". Which side are you backing to advance to the semi-finals?
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