"One of those days", added Djokovic, whose defeat came on a day the women's draw lost it's top two seeds - world number one Naomi Osaka and number two Simona Halep.
Not since 2009 had Kohlschreiber beaten Djokovic but the 35-year-old upstaged the Serb to earn a last-16 showdown with Gael Monfils.
The Swiss faced a dozen break points in the third set alone, including four at 6-5 as he tried to serve out the match.
A match with Federer is another one to relish, Wawrinka said, despite their lopsided record.
New Zealand police hunt 'active' mosque shooter
People in central Christchurch have been urged to stay indoors and report any suspicious behaviour immediately to authorities. There was no official information on casualties but a Bangladesh cricket team spokesman said none of the players were hurt.
"I'm really happy about it, especially since I didn't really do anything before this", he said.
He made no mistake on his second chance, however, firing a sideline-skimming forehand to seal the milestone win on his first match point.
Nadal extended his FedEx ATP Head2Head series lead against Schwartzman to 7-0, with five of his victories coming in straight sets.
But Djokovic, who shares the record for most titles at the ATP 1000 event with five alongside Federer, was stunned by Philipp Kohlschreiber.
Rafael Nadal and Roger Federer eased through as Novak Djokovic departed on a day of upsets at the Indian Wells Masters. I think he probably struggled throughout a little bit.
Oil hits four-months highs, Brent reaches $68 on tighter supply
USA said it plans to impose "very significant" Venezuela-related sanctions against financial institutions in the coming days. Energy Information Administration , U.S. commercial crude inventories fell last week as refineries hiked output.
"The previous days here in Indian Wells helped me a lot to get back to my top level physically and also to play good tennis again", Thiem said. I was able to mix up my game, cover my serve, be risky on the return.
Federer was on later in the afternoon against Indian Wells challenger victor Kyle Edmund. "Maybe take some rhythm away from Stan, like I always try to do, but you can't always make it work".
Kecmanovic became the first lucky loser to reach the quarterfinals since the tournament achieved Masters 1000 status in 1990.
He next will take on 13th-ranked Russian Karen Khachanov, who beat world number nine John Isner 6-4, 7-6 (7/1).
Timelapse Video Shows Arrival of 'Bomb Cyclone' in Aurora, Colorado
The storm could also cause flooding, as rain falls on accumulated snow and rivers clogged with ice begin to rise. The National Weather Service predicts it will be a "highly impactful winter storm" that tears through the region.