Police say they've responded to an active shooter situation at the Fifth Third Bank building in downtown Cincinnati and there are multiple injuries.
Almost three hours after the incident, several streets in downtown Cincinnati remained closed to traffic.
A spokeswoman for Fifth Third Bank says the company would comment later.
Streets and sidewalks around the building were closed. He then entered the lobby where he exchanged fire with law enforcement.
It wasn't clear if the shooter was one of the reported casualties.
The city's police chief, Eliot Isaac, said he could not confirm local media reports that the gunman was a disgruntled employee of the bank, and said he had no information that the victims were targeted. Police swarmed his apartment in North Bend, Ohio, about 15 miles (24 kilometers) away. He died at the scene, Isaac said. "We're in the very early stages" of the investigation.
DOJ: We will examine social media firms that "may be hurting competition"
A spokesperson for Twitter declined to comment, but in past hearings Twitter officials have affirmed the gravity of the situation. Leonard Lance speaks out on what he plans to ask Twitter CEO Jack Dorsey on the handling of conservative content.
Federal agents were on the scene as police searched through the building.
Londberg quoted the witness as saying, "I saw a guy in a white shirt walking around and shooting like this" (the witness held up his right arm straight in front of him) 'bing bing bing bing, '" and then added, "He ran. "Avoid area of fountain square in downtown Cincinnati". She said after repeatedly hearing shots, she went to the window and saw people running and ducking for cover as officers started shooting into the bank.
"There was definitely a lot of blood involved", Zach Fritzhand, who works nearby, said.
Journalist Nick Swartsell wrote, "Witness Leonard Cain: two shot, including a woman who was heading into the bank and a man, Cain's boss, who works for Gilbane Construction".
Authorities were trying to determine what may have motivated the gunman to carry out the rampage but have said he acted alone. "You know, these are things that we see happening across the country, and we all have to be vigilant and prepared to deal with these situations".
One unnamed eyewitness, a construction worker, told WLWT television that he heard at least six gunshots before police arrived. As he helped others take cover, Montoya said Newcomer was injured in the building's basement and ran to get help from medics. One victim was determined dead at the scene and two died at the hospital. As previously announced, two other victims received at UC Medical Center are deceased.
Nike's new ad featuring Colin Kaepernick released
A roadie and "ex-Marine" chopped the Nike swoosh off his socks and posted a picture that went. you guessed it, viral. WATCH: Nike calls Kaepernick inspirational, but as Eric Sorensen reports, it's ignited a firestorm.
"No other industrialized country has this level of multiple active shootings on a regular basis, nearly on a daily basis", Cranley said.
Fountain Square is often the site of concerts, dancing, food trucks and other events around lunchtime or in the evenings.
"We send our prayers to the victims and their families", said Cincinnati Mayor John Cranley.
Hamilton County Prosecutor Joe Deters said the rapid police response probably prevented many more casualties.
"We as a country have to figure out how to end it", Cranley said.
BMW Championship: Woods, McIlroy tied at 8 under
A birdie at 18 saw him turn in six-under 29, the first time he's broken 30 for nine holes on the PGA Tour since 2007. When he was 9-under with four holes left - the last one a par 5 - he started thinking about breaking 60.