Dele Alli will also miss out tomorrow because of a hamstring injury he suffered playing for England last week, but Heung-min Son will be available again after his lengthy stint on global duty with South Korea.
Pochettino said: "He already knew that it was a big mistake".
Pochettino said that "of course" Lloris would remain captain, explaining: "He's the first that regrets everything".
Marcus Rashford scores against Spain after stunning pass from Luke Shaw
But if he wants to achieve an ambition to be recognised as a great goalscorer it is just not going to happen there . However, whether he can show his talent at United long term remains to be seen.
"Of course he doesn't feel great".
"Everyone can make a mistake, he made a mistake and he is suffering".
"It's a massive lesson for everyone". We are not God and cannot judge people. He's the first, he told me, "Gaffer it's a massive lesson for me".
Pochettino is also frustrated by the absence of Alli for both the visit of Liverpool and then the trip to Inter Milan on Tuesday evening as the club launch their Champions League campaign.
Hurricane Florence strengthens to a Category 3 storm
ET advisory that Florence was about 625 miles (1,005 kilometers) southeast of Bermuda, moving west northwest at 9 mph (15 kmh). Still said it been "quite some time" since a storm of Florence's magnitude had approached Southeastern North Carolina.
Tottenham are also understood to have fined the World Cup victor £250,000, which is the equivalent of two weeks' wages, and warned him about his future conduct.
Pochettino was less illuminating about talk Toby Alderweireld may get a new contract.
"He suffered a small injury after 20 minutes in the game against Spain at Wembley".
Spurs confirmed yesterday that he would be unavailable again for this weekend's clash against Liverpool due to the problem and that he is expected to be out for "several weeks" which will result in Michel Vorm given an extended run in the side.
Florence isn’t alone. More tropical storms are brewing
Forecasters said Isaac will bring several inches of rain to some locations and possibly life-threatening surf conditions. At 5 a.m., the storm was centered 575 miles (925 km) southeast of Cape Fear, North Carolina, moving at 17 mph (28 kph).
"Hopefully everything is going well and he can be back as soon as possible, like Dele".