Only half of the men's top 10 seeds have made Wimbledon third round with 2017 finalist Marin Cilic joining the casualty list on day four at the All England Club.
Serena Williams in action against Viktoriya Tomova of Bulgaria during their third round match at Wimbledon on Wednesday.
The 36-year-old American now can not meet a top 32 player until the semi-finals after the scattering of the seeds this week.
It is the biggest win of Pella's career and he is now in the third round of a Grand Slam for the first time.
If anyone doubted Serena Williams was worth consideration as a victor of this tournament for an eighth time - let alone the 25th seeding that has caused a minor stir in the locker room - she provided the most emphatic statement of intent with her third straight-sets win of the week to reach the fourth round on a wave of growing self-belief.
Suarez limps off in Uruguay training as Cavani sits out team session
In Russia, the same narrative persisted with Ronaldo's hat-trick in the thriller against Spain and the victor against Morocco. The knockout stages of the World Cup start on Saturday with teams looking to book their places in the quarterfinals.
Venus, seeded ninth, joined Petra Kvitova, Maria Sharapova, Caroline Wozniacki and Sloane Stephens as the most high-profile casualties of Wimbledon's year of the giant-killers in the women's singles.
Anderson earlier became the first man through to the fourth round after beating Philipp Kohlschreiber 6-3 7-5 7-5.
Struff, who had recovered from 2-0 down to win both of his opening two matches, settled down in the second set and was clearly becoming more comfortable in the alien and daunting environment of Centre.
But instead the 38-year-old was worn down by Dutch 20th seed Bertens in a dramatic third round clash lasting two hours and 40 minutes in sweltering heat on Court One.
Del Potro faces Benoit Paire in the third round after the Frenchman upset 26th-seeded Canadian Denis Shapovalov.
Michelle Froome: 'Chris will ride in Tour de France'
CHRIS FROOME faces a fight to defend his Tour de France title after the race's organisers tried to ban him from the startline. A decision is set to be made the following day, with just three days to go until the start in the Vendee on July 7.
Keys also came up short with a comeback attempt after fighting back from a set and two breaks down, losing 7-5, 5-7, 6-4. Happy for the victory and happy with way I played.
The seven-time champion came from a break down in the first set to get past Kristina Mladenovic 7-5, 7-6 (2).
Amazon announces Prime Day 2018 with more than one million deals
Finally, Amazon will be hosting events in the run up to Prime Day with London's "Unbox Prime" event taking place on 15th July. U.S. e-commerce company Amazon's annual shopping event Prime Day will be available to Singaporeans for the first time ever.